BDBM50583341 CHEMBL5092805

SMILES CCc1c[nH]c2ncc(cc12)-c1ccc(N)c(C(=O)N(C)C)c1F

InChI Key InChIKey=PBRKEKVJQVXNEQ-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50583341   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583341(CHEMBL5092805)Copy SMILESCopy InChI

Affinity DataKi:  0.470nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
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TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583341(CHEMBL5092805)Copy SMILESCopy InChI

Affinity DataIC50: 700nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by TDI- high-throughput based mass spectrometry methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL