BDBM50583345 CHEMBL5078498

SMILES CN(C)C(=O)c1c(N)ccc(c1F)-c1cnc2NCC3(CC3)c2c1C

InChI Key InChIKey=UXGSDFHEOAQQBF-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50583345   

LigandPNGBDBM50583345(CHEMBL5078498 | US12208088, Compound 30)
Affinity DataKi:  43nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50583345(CHEMBL5078498 | US12208088, Compound 30)
Affinity DataKi:  53.9nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50583345(CHEMBL5078498 | US12208088, Compound 30)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by TDI- high-throughput based mass spectrometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed