BDBM50584927 CHEMBL5074753

SMILES COc1cc(cc(c1O)OC)C(=O)N2[C@H]3Cc4ccccc4[C@@H]2CNC3=O

InChI Key InChIKey=JRZNNUGTWNEAQO-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50584927   

TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584927(CHEMBL5074753)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584927(CHEMBL5074753)
Affinity DataIC50: 2.12E+4nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584927(CHEMBL5074753)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584927(CHEMBL5074753)
Affinity DataIC50: 3.16E+4nMAssay Description:Displacement of Alexafluor 647-JQ1 from GST-BRD4 BD1 BD2 (44 to 460 residues) (unknown origin) incubated for 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed