BDBM50585315 CHEMBL5070579

SMILES COc1cc(N(C)CCN(C)CC#C)c(NC(=O)C=C)cc1Nc1nccc(Nc2ccn(C)n2)n1

InChI Key InChIKey=IFKCLMDEPDCIBC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50585315   

TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585315(CHEMBL5070579)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of EGFR T790M/C797S double mutant (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585315(CHEMBL5070579)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of EGFR L858R/T790M (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585315(CHEMBL5070579)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR del19 (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585315(CHEMBL5070579)
Affinity DataIC50: 51nMAssay Description:Inhibition of wild type EGFR (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandPNGBDBM50585315(CHEMBL5070579)
Affinity DataIC50: 51nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed