BDBM50585632 CHEMBL5070593

SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Nc2ccc(CC(=O)Nc3cccc(F)c3)cc2)n1

InChI Key InChIKey=QJOKMKBZEMLHIM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50585632   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 19nMAssay Description:Inhibition of human RET V804M mutant using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by Lin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 88nMAssay Description:Inhibition of CSF-1R (unknown origin) using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 96nMAssay Description:Inhibition of Aurora A (unknown origin) using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 100nMAssay Description:Inhibition of TRKA (unknown origin) using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 113nMAssay Description:Inhibition of FLT3 (unknown origin) using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin) using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50585632(CHEMBL5070593)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of NEK2 (unknown origin) using 5-FAM- peptide as substrate preincubated for 1 hr followed by substrate addition in presence of ATP by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed