BDBM50586051 CHEMBL5088430

SMILES CN1C2N(CCc3c2[nH]c2ccc(OCc4ccc(\C=C\C(=O)Nc5ccccc5N)cc4)cc32)C(=O)c2cc(F)ccc12

InChI Key InChIKey=UQWFSWVIRVHASZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50586051   

TargetHistone deacetylase 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50586051(CHEMBL5088430)
Affinity DataIC50: 320nMAssay Description:Inhibition of full-length recombinant human HDAC1 expressed in Baculovirus expression system using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50586051(CHEMBL5088430)
Affinity DataIC50: 690nMAssay Description:Inhibition of full-length recombinant C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50586051(CHEMBL5088430)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of full-length recombinant N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50586051(CHEMBL5088430)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant His-tagged human HDAC3 expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50586051(CHEMBL5088430)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of recombinant full length C-terminal GST tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed