BDBM50586181 CHEMBL5082136

SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1nc(Nc2ccc(cc2)C(=O)NCCCCOc2ccc(cc2)C2CCC(=O)NC2=O)nc2[nH]ccc12

InChI Key InChIKey=JQXUGPKGNONGRJ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586181   

TargetTyrosine-protein kinase JAK2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586181(CHEMBL5082136)
Affinity DataKd:  0.140nMAssay Description:Binding affinity to JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586181(CHEMBL5082136)
Affinity DataIC50: 20nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed