BDBM50587675 CHEMBL4303523

SMILES CCC(=O)Nc1cccc(c1)Oc2c(cnc(n2)Nc3ccc(cc3OC)N4CCN(CC4)C)Cl

InChI Key InChIKey=SDGJBAUIGHSMRI-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50587675   

TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged NUAK1 (unknown origin) expressed in HEK293 cells using ALNRTSSDSALHRRR as substrate incubated for 30 mins in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 100nMAssay Description:Inhibition of GST-tagged NUAK2 (unknown origin) expressed in HEK293 cells using ALNRTSSDSALHRRR as substrate incubated for 30 mins in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged human NUAK2 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP by cerenko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataKd:  130nMAssay Description:Binding affinity to EGFR L858R/T790M mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to EGFR L858R mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to EGFR T790M mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to wildtype EGFR (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed