BDBM50588464 CHEMBL5191989

SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@@H]3CCC[C@H]3Oc3ccc(Cl)cc3)ncnc12

InChI Key InChIKey=QHCCYMQVQIXGMM-UHFFFAOYSA-N

Data  2 KI  2 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50588464   

TargetAdenosine receptor A1(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataKd:  55nMAssay Description:Inhibition of CA200645 binding to NanoLuc-fused rat adenosine A1 receptor expressed in HEK293 cells assessed as kinetic dissociation constant by Nano...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataKi:  83nMAssay Description:Inhibition of CA200645 binding to NanoLuc-fused rat adenosine A1 receptor expressed in HEK293 cells measured for 10 mins by NanoBRET competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataKi:  138nMAssay Description:Inhibition of CA200645 binding to NanoLuc-fused human adenosine A1 receptor expressed in HEK293 cells measured for 10 mins by NanoBRET competition bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataKd:  195nMAssay Description:Inhibition of CA200645 binding to NanoLuc-fused human adenosine A1 receptor expressed in HEK293 cells assessed as kinetic dissociation constant by Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataEC50:  7.94E+3nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50588464(CHEMBL5191989)
Affinity DataEC50:  1.38E+4nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed