BDBM50590221 CHEMBL5180782::US20240308980, Ex-4.2

SMILES Cn1cc(cn1)-c1cccc(n1)C(=O)Nc1cc(ncc1C(F)(F)F)N1CC[C@H](C1)C(C)(C)O

InChI Key InChIKey=HRRUGRNBEPWHFW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50590221   

LigandPNGBDBM50590221(CHEMBL5180782 | US20240308980, Ex-4.2)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GST20 tagged truncated LRRK2 G2019S mutant assessed as substrate phosphorylation preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
LigandPNGBDBM50590221(CHEMBL5180782 | US20240308980, Ex-4.2)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human LRRK2 G2019S mutant expressed in human SH-SY5Y cells assessed as inhibition of tetracycline induced LRRK2 phosphorylation at Ser9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50590221(CHEMBL5180782 | US20240308980, Ex-4.2)
Affinity DataIC50: 63nMAssay Description:Inhibition of CLK2 (unknown origin) assessed as substrate phosphorylation using coumarin and fluorescein-labeled peptide as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50590221(CHEMBL5180782 | US20240308980, Ex-4.2)
Affinity DataIC50: 1.63E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

LigandPNGBDBM50590221(CHEMBL5180782 | US20240308980, Ex-4.2)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human ERG tail current in cells at -80 mV holding potential by PatchXpress automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
LigandPNGBDBM50590221(CHEMBL5180782 | US20240308980, Ex-4.2)
Affinity DataIC50: 2.99E+4nMAssay Description:Inhibition of human NaV1.5 expressed in HEK293 by PatchXpress automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed