BDBM50590541 CHEMBL5181467

SMILES CN1CCC(COc2nc(N3CCC4(CN(C4)C(=O)C=C)CC3)c3cc(Cl)c(c(F)c3n2)-c2c(C)ccc3[nH]ncc23)CC1

InChI Key InChIKey=DEJULSHQAMEKHI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50590541   

TargetGTPase KRas(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50590541(CHEMBL5181467)
Affinity DataIC50: 130nMAssay Description:Inhibition of biotinylated Avi-tagged GDP-bound KRAS G12C mutant (1 to 185 residues) (unknown origin) assessed as inhibition of KRAS G12C mutant/SOS/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed