BDBM50590838 CHEMBL5204650

SMILES NNC(=O)c1csc2nc(CN3CCOCC3)c(-c3ccc(Br)cc3)n12

InChI Key InChIKey=TXZRYLZHQIMGPZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50590838   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50590838(CHEMBL5204650)
Affinity DataIC50: 121nMAssay Description:Inhibition of recombinant human HER2 incubated for 40 to 45 mins and measured after 15 mins by Kinase-Glo Max assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50590838(CHEMBL5204650)
Affinity DataIC50: 419nMAssay Description:Inhibition of recombinant human EGFR incubated for 40 to 45 mins and measured after 15 mins by Kinase-Glo Max assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDihydrofolate reductase(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50590838(CHEMBL5204650)
Affinity DataIC50: 3.28E+3nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli incubated for 15 mins and measured by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed