BDBM50590928 CHEMBL2178735

SMILES Nc1ccc(cn1)C(=O)Nc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1

InChI Key InChIKey=YBPIBGNBHHGLEB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50590928   

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of N-terminal His-tagged human PIKfyve expressed in Sf9 insect cells incubated for 1 hr by enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of PIKfyve (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 74nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 74nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of GST-tagged Ptdlns3p P110alpha (unknown origin) expressed in baculovirus infected insect cells incubated for 15 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target(Homo sapiens)TBA
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae GST-tagged Fab1 incubated for 15 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details