BDBM50591949 CHEMBL5185001

SMILES Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3n(ncc23)C2CCOCC2)n[nH]1

InChI Key InChIKey=JWPYZYBMSBDDCD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591949   

TargetSerine/threonine-protein kinase PLK4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591949(CHEMBL5185001)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human PLK4 incubated for 60 mins by Lanthascreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591949(CHEMBL5185001)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PLK4 (unknown origin) incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591949(CHEMBL5185001)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of TRKA (unknown origin) using TK peptide as substrate incubated for 30 mins in presence of ATP by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591949(CHEMBL5185001)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of PAK4 (unknown origin) incubated for 60 mins by time-resolved HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed