BDBM50593283 CHEMBL5177497

SMILES C[C@@H](NC1(C)CCC1)c1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cccc(c1)C1(COC1)[C@@H](F)c1nncn1C

InChI Key InChIKey=NJOKETZTARBFPO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50593283   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50593283(CHEMBL5177497 | US20250230147, Compound 247)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as reduction in LCK ubiquitination preincubated for 60 mins followed by kinase mix addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50593283(CHEMBL5177497 | US20250230147, Compound 247)
Affinity DataIC50: 7.60nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM50593283(CHEMBL5177497 | US20250230147, Compound 247)
Affinity DataIC50: 11nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent