BDBM50593284 CHEMBL5177770

SMILES CC(C)[C@@H]1CN(C)CCN1Cc1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cc(cc(OC2CCCC2)n1)C1(Cc2nncn2C)COC1

InChI Key InChIKey=KLPFKFUBXIWSDL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593284   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50593284(CHEMBL5177770)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as reduction in LCK ubiquitination preincubated for 60 mins followed by kinase mix addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50593284(CHEMBL5177770)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of N-terminal Avi-tagged human Cbl-b (40 to 426 residues) expressed in Escherichia coli by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed