BDBM50593286 CHEMBL5178829

SMILES CCNc1cc(cc(c1)C1(Cc2nncn2C)CCC1)N1Cc2c(cc(CNC3(C)CCC3)cc2C(F)(F)F)C1=O

InChI Key InChIKey=KVHFSZCGFDFVQF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50593286   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM50593286(CHEMBL5178829 | US20250230147, Compound 463)
Affinity DataIC50: 3.5nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50593286(CHEMBL5178829 | US20250230147, Compound 463)
Affinity DataIC50: 6nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as reduction in LCK ubiquitination preincubated for 60 mins followed by kinase mix addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50593286(CHEMBL5178829 | US20250230147, Compound 463)
Affinity DataIC50: 6nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent