BDBM50593948 CHEMBL5195033

SMILES Cc1ccc(cn1)-c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=HOUPVYQTKKURFZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50593948   

TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50593948(CHEMBL5195033)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using TK-sub biotin peptide substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50593948(CHEMBL5195033)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using TK-sub biotin peptide substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50593948(CHEMBL5195033)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of TRKA G623R mutant (unknown origin) using TK-sub biotin peptide substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50593948(CHEMBL5195033)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant human His-tagged TRKA cytoplasmic domain (441 to 796 residues) expressed in insect cells using TK-sub biotin peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed