BDBM50594136 CHEMBL5190244

SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2c(ncn12)[C@H](C)CC)-c1ccc(nc1)N1CCNCC1

InChI Key InChIKey=ZMMJXKCWHMTACI-HXUWFJFHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50594136   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594136(CHEMBL5190244)
Affinity DataIC50:  76nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594136(CHEMBL5190244)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed