BDBM50595425 CHEMBL5208957

SMILES O=C(N[C@@H](c1ccccc1)c1cccc(OCc2nc(C(=O)OCCCCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)co2)c1)O[C@H]1CN2CCC1CC2

InChI Key InChIKey=UTMUSTVNAHXQQF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50595425   

TargetBeta-2 adrenergic receptor(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595425BDBM50595425(CHEMBL5208957)
Affinity DataKi:  0.0501nMAssay Description:Displacement of 125I-cyanopindolol from human beta2 adrenoceptor expressed in CHO-K1 cell membrane measured after 1 hr by Cheng-prusoff equation anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595425BDBM50595425(CHEMBL5208957)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cell membrane measured after 2 hr by Cheng-prusoff equat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor(Guinea pig)
Chiesi Farmaceutici

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595425BDBM50595425(CHEMBL5208957)
Affinity DataIC50: 0.398nMAssay Description:Invivo antagonist activity at muscarinic M3 receptor activity in Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol induced contra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Chiesi Farmaceutici

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595425BDBM50595425(CHEMBL5208957)
Affinity DataIC50: 0.398nMAssay Description:Invivo agonist beta2 adrenoceptor activity in Dunkin-Hartley guinea pig trachea assessed as histamine induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed