BDBM50595708 CHEMBL5202426

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(F)(F)c2cnc(nc2)-c2ccc(cc2)C(C(=O)NO)c2ccccc2F)C(C)(C)C)cc1

InChI Key InChIKey=JCIGJBGCHCAMMB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50595708   

TargetHistone deacetylase 7(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50595708(CHEMBL5202426)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant HDAC7 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50595708(CHEMBL5202426)
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant HDAC5 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50595708(CHEMBL5202426)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant HDAC9 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50595708(CHEMBL5202426)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant HDAC4 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50595708(CHEMBL5202426)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat E6.1 cells using Boc-Lys(Ac)-AMC as substrate incubated for 24 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed