BDBM50597033 CHEMBL5204916

SMILES Cc1ccc2ccc(N[C@H]3CC[C@H](CNc4ncc(cn4)C(C#N)C(=O)NC4COC4)CC3)nc2c1Cl

InChI Key InChIKey=NJUIOXKEPURYIM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50597033   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597033(CHEMBL5204916)
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH2 in human G-401 cells assessed as reduction in H3K27 methylation incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed