BDBM50597483 CHEMBL5209466

SMILES COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(CC1)c1ccncc1

InChI Key InChIKey=SQSIIZGBYLJBMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50597483   

TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597483(CHEMBL5209466)
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597483(CHEMBL5209466)
Affinity DataIC50: 1.00E+4nMAssay Description:Time dependent inhibition of CYP1A2 in pooled human liver microsomes using midazolam as substrate preincubated for 30 mins in presence of NADPH follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed