BDBM50598682 CHEMBL5206444

SMILES CC(C)c1ccc(N2CC(CS(C)(=O)=O)C2)c2cnc(Nc3ccnc(n3)N3CC[C@@H](O)[C@@](C)(F)C3)cc12

InChI Key InChIKey=LFHIIRYLQNMSCR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50598682   

TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50: 385nMAssay Description:Inhibition of N-terminal GST tagged recombinant wild type human EGFR expressed in baculovirus infected Sf9 insect cells expression system using 5-FAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of wild type EGFR in human A-431 cells preincubated for 4 to 5 hrs followed by EGF stimulation for 10 mins by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed