BDBM50598683 CHEMBL5196495

SMILES CC(C)c1ccc(N2C[C@H](CS(C)(=O)=O)[C@H]2C)c2cnc(Nc3ccnc(n3)N3CC[C@@H](O)[C@@](C)(F)C3)cc12

InChI Key InChIKey=VKTRKEAYXURHJJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598683   

TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type EGFR L858R/T790M/C797S triple mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 505nMAssay Description:Inhibition of N-terminal GST tagged recombinant wild type human EGFR expressed in baculovirus infected Sf9 insect cells expression system using 5-FAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 505nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of wild type EGFR in human A-431 cells preincubated for 4 to 5 hrs followed by EGF stimulation for 10 mins by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed