BDBM50599224 CHEMBL5176061::US11866405, Example 68

SMILES COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@H]1CC[C@@]2(CN(C)C(=O)C2)CC1

InChI Key InChIKey=RXVNKPUWTRJPHR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50599224   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50599224(CHEMBL5176061 | US11866405, Example 68)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus infected insect cells using KKARFSRFAGSSPSQSSMVAR as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50599224(CHEMBL5176061 | US11866405, Example 68)
Affinity DataIC50: 1.60nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent