BDBM50600093 CHEMBL5206780

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1ccc2C(=O)CC3(CCOCC3)Oc2c1

InChI Key InChIKey=RTUYPTJYSVBXGS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50600093   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant cRAF measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50600093(CHEMBL5206780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed