BDBM50601801 CHEMBL5169432

SMILES CN(C)C(=O)c1cccc(c1)-c1cccc(c1)-n1ncc(C(O)=O)c1C1CC1

InChI Key InChIKey=HPTUBKDOPRIRSX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50601801   

TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601801(CHEMBL5169432)
Affinity DataIC50:  370nMAssay Description:Inhibition of 5'-TAMRA tagged NRF2 (unknown origin)/human recombinant N-terminal Avi tagged KEAP-1 (321 to 609 residues) expressed in Baculovirus sys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601801(CHEMBL5169432)
Affinity DataEC50:  1.40E+3nMAssay Description:Induction of Nrf2 in human BEAS-2B cells assessed as increase in NQO1 protein level incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601801(CHEMBL5169432)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 5'-TAMRA tagged NRF2 (unknown origin)/human recombinant N-terminal Avi tagged KEAP-1 (321 to 609 residues) expressed in Baculovirus sys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB