BDBM50604024 CHEMBL5193283

SMILES OCc1cc(ncc1-c1ccc(cc1)C1(CCC1)C(=O)Nc1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=GXMFNZRLSVZUJB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50604024   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604024(CHEMBL5193283)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604024(CHEMBL5193283)
Affinity DataIC50: 3nMAssay Description:Inhibition of IDO1 in IFN gamma-stimulated human HeLa cells measured after 48 hrs by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604024(CHEMBL5193283)
Affinity DataIC50: 905nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604024(CHEMBL5193283)
Affinity DataIC50: 1.19E+7nMAssay Description:Inhibition of MK-499 binding to hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed