BDBM50604699 CHEMBL5198894

SMILES COc1cc(Oc2c(sc3c2ccc2[nH]ncc32)-c2cc(F)c(F)cc2C(C)(F)F)ccc1NC1CN(CCCF)C1

InChI Key InChIKey=FUONBUGRIAXKMC-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50604699   

TargetEstrogen receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50604699(CHEMBL5198894)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at ERalpha expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of estradiol by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEstrogen receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50604699(CHEMBL5198894)
Affinity DataEC50:  2.60nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50604699(CHEMBL5198894)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human ERG potassium channel expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed