BDBM50605158 CHEMBL5183862

SMILES CN1CCNC(=O)CCCCOc2cc(C#Cc3cnc4ccc1nn34)c(C)c(c2)C(=O)Nc1cc(Cl)cc(c1)C(F)(F)F

InChI Key InChIKey=SSTIMZHRJKXPQP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50605158   

TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605158(CHEMBL5183862)
Affinity DataIC50: 32nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 400 uM ATP by FRET based Z'-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605158(CHEMBL5183862)
Affinity DataIC50: 102nMAssay Description:Inhibition of TRKC (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 50 uM ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605158(CHEMBL5183862)
Affinity DataIC50: 128nMAssay Description:Inhibition of N-terminal hexahistidine tagged TRKA (485 to 795 residues) (unknown origin) expressed in Sf9 cells using Ser/Thr 06 peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed