BDBM50605416 CHEMBL5188281

SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cn(c2ccccc12)S(=O)(=O)C(C)C)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=CLMUEOBXJXGCLL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50605416   

TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605416BDBM50605416(CHEMBL5188281)
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605416BDBM50605416(CHEMBL5188281)
Affinity DataIC50: 24nMAssay Description:Inhibition of EGFR 19 del/T790M/C797S mutant (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605416BDBM50605416(CHEMBL5188281)
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR del19/T790M/C797S triple mutant (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605416BDBM50605416(CHEMBL5188281)
Affinity DataIC50: 145nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605416BDBM50605416(CHEMBL5188281)
Affinity DataIC50: 222nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605416BDBM50605416(CHEMBL5188281)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed