BDBM50605474 CHEMBL5189857

SMILES Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=GPXQUPCJIJBXHJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50605474   

TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 76nMAssay Description:Inhibition of STING (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 76nMAssay Description:Inhibition of STING in human THP1-Lucia ISG cells assessed as reduction in luciferase activity preincubated for 1.5 hrs followed by 2,3-cGAMP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 107nMAssay Description:Inhibition of mouse STING in MEF assessed as inhibition of cGAMP-induced Ifnb mRNA expression measured after 6 hrs by quantitative PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 128nMAssay Description:Inhibition of mouse STING in mouse BMDM assessed as inhibition of cGAMP-induced Ifnb mRNA expression measured after 6 hrs by quantitative PCR analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 270nMAssay Description:Inhibition of cGAMP-induced mouse STING transfected in human THP-1 cells preincubated with compound for 6 hrs followed by cGAMP addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 490nMAssay Description:Inhibition of cGAMP-induced STING R232 mutant transfected human THP-1 cells preincubated with compound for 6 hrs followed by cGAMP addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 503nMAssay Description:Inhibition of human STING in human foreskin fibroblast (HFF) assessed as inhibition of cGAMP-induced Ifnb mRNA expression measured after 6 hrs by qua...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of cGAMP-induced STING HAQ mutant transfected in human THP1-Blue ISG cells preincubated with compound for 6 hrs followed by cGAMP addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of cGAMP-induced STING S154 mutant transfected in human THP-1 cells preincubated with compound for 6 hrs followed by cGAMP addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605474BDBM50605474(CHEMBL5189857)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of diABZI-induced STING HAQ mutant transfected in human THP1-Blue ISG cells preincubated with compound for 6 hrs followed by diABZI additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed