BDBM50605637 CHEMBL5172007

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(NC(=O)CCCCCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=RBIXMXHAUANJLQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50605637   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Sun Yat-Sen University Cancer Center

Curated by ChEMBL
LigandPNGBDBM50605637(CHEMBL5172007)
Affinity DataIC50: 530nMAssay Description:Inhibition of EZH2 (unknown origin) using H3-derivede peptide (21 to 44) as substrate incubated for 60 min in presence of SAM by MTase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Sun Yat-Sen University Cancer Center

Curated by ChEMBL
LigandPNGBDBM50605637(CHEMBL5172007)
Affinity DataIC50: 580nMAssay Description:Displacement of fluorescein-labeled JQ1 from His6/TEV cleavage site fused human BRD4 (residues N44 to E168) expressed in Escherichia coli BL21 (DE3) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed