BDBM50606245 CHEMBL5186525

SMILES OC(=O)c1ccc(CNC(=O)c2c(Cc3ccc(F)cc3)sc3COCCc23)cc1

InChI Key InChIKey=WXDKVCQSVUOFSK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50606245   

TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human EP4 receptor expressed in CHO cells coexpressing tTA-dependent luciferase reporter and beta arrestin 2-TEV assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at human EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as reduction in PGE2-mediated cAMP accumulation preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at mouse EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP1 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP3 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP2 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50606245(CHEMBL5186525)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG potassium channel transfected in HEK293 cells by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed