BDBM50609348 CHEMBL5272595

SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F

InChI Key InChIKey=ZGVMLURVURNUQI-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50609348   

TargetHepatocyte growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataIC50: 90nMAssay Description:Inhibition of his-tagged c-MET D1228V mutant (1050 to 1346 residues) (unknown origin) by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataKd:  650nMAssay Description:Binding affinity to his-tagged c-MET D1228V mutant (1050 to 1346 residues) (unknown origin) assessed as dissociation constant by surface plasmon reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataIC50: 900nMAssay Description:Inhibition of his-tagged wild type c-MET (1050 to 1346 residues) (unknown origin) by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataKd:  7.20E+3nMAssay Description:Binding affinity to his-tagged wild type c-MET (1050 to 1346 residues) (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of his-tagged c-MET D1228V mutant (1050 to 1346 residues) (unknown origin) in human NCI-H1993 cells by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of his-tagged wild type c-MET (1050 to 1346 residues) (unknown origin) in human NCI-H1993 cells by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed