BindingDB BDBM50611755 CHEMBL5281283

BDBM50611755 CHEMBL5281283

SMILES C[C@@H]1CCN(C[C@@H]1n1ccc2cnc3[nH]ccc3c12)C(=O)CC#N

InChI Key InChIKey=UQVAOELSLJXOMB-DOMZBBRYSA-N

Data 34 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50611755

Tyrosine-protein kinase JAK3(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: 0.440nMAssay Description:Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase JAK2(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: 1nMAssay Description:Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase JAK2(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: 0.300nMAssay Description:Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Tyrosine-protein kinase JAK1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: 1.10nMAssay Description:Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase JAK1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: 0.460nMAssay Description:Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Tyrosine-protein kinase ABL1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase BTK(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase CSK(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Epidermal growth factor receptor(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Ephrin type-A receptor 2(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of EphA2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Focal adhesion kinase 1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Insulin-like growth factor 1 receptor(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Angiopoietin-1 receptor(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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High affinity nerve growth factor receptor(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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Aurora kinase C(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Bone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of BMPR1A (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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Calcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of CAMK2alpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Cyclin-dependent kinase 2(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Serine/threonine-protein kinase Chk1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Casein kinase I isoform delta(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of CHKdelta (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details PubMed

Glycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of IKKB (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Mitogen-activated protein kinase 8(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Dual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of MAP2K1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Mitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of MAP3K1 (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

MAP kinase-activated protein kinase 2(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Mitogen-activated protein kinase 11(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of P38beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Ribosomal protein S6 kinase beta-1(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: >1.00E+3nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Tyrosine-protein kinase JAK3(Homo sapiens (Human))TBA

BDBM50611755(CHEMBL5281283)

IC50: 0.140nMAssay Description:Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details PubMed

Filter my 34 hits

Targets 31▿
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Tyrosine-protein kinase JAK1 2
- Ephrin type-A receptor 2 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase ITK/TSK 1
- Insulin-like growth factor 1 receptor 1
- High affinity nerve growth factor receptor 1
- Bone morphogenetic protein receptor type-1A 1
- Epidermal growth factor receptor 1
- Mitogen-activated protein kinase 8 1
- Angiopoietin-1 receptor 1
- Ribosomal protein S6 kinase beta-1 1
- Glycogen synthase kinase-3 beta 1
- Aurora kinase C 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Casein kinase I isoform delta 1
- Mitogen-activated protein kinase 11 1
- Tyrosine-protein kinase ABL1 1
- Mitogen-activated protein kinase kinase kinase 1 1
- Tyrosine-protein kinase CSK 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Focal adhesion kinase 1 1
- RAC-alpha serine/threonine-protein kinase 1
- Cyclin-dependent kinase 2 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- Serine/threonine-protein kinase Chk1 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- MAP kinase-activated protein kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- Proto-oncogene tyrosine-protein kinase Src 1
Publications 0▿
Institutions 0▿
Affinity: 0.14 to 1.0E+3 nM▿
- IC50 34
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0