BDBM50613321 CHEMBL5284206

SMILES Oc1cc(Cl)c(C2CC2)c(c1)-c1ncc2c(nc(OC[C@]34CCCN3C[C@@H](F)C4)nc2c1F)N1CC2CCC1CN2

InChI Key InChIKey=UIVPVMFQHOTOOG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50613321   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50613321(CHEMBL5284206)
Affinity DataIC50: 50nMAssay Description:Inhibition of human KRAS G12D mutant in human AGS cells assessed as reduction in phosphorylated ERK level incubated for 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50613321(CHEMBL5284206)
Affinity DataIC50: 50nMAssay Description:Inhibition of human KRAS G12D mutant in human AGS cells assessed as reduction in phosphorylated ERK level incubated for 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed