BDBM50613353 CHEMBL5284517

SMILES N[C@@H](CCN(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)S(=O)(=O)c1cnc(Cl)cn1)C(O)=O

InChI Key InChIKey=NUFHSMQFUWVWAB-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50613353   

TargettRNA (cytosine(38)-C(5))-methyltransferase(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50613353(CHEMBL5284517)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length human DNMT2 expressed in bacteria using tRNA-Asp as substrate and 3H-SAM as cosubstrate by tritium incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50613353(CHEMBL5284517)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to full-length human DNMT2 expressed in bacteria assessed as apparent dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargettRNA (cytosine(38)-C(5))-methyltransferase(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50613353(CHEMBL5284517)
Affinity DataKd:  2.60E+3nMAssay Description:Displacement of FTAD from full-length human DNMT2 expressed in bacteria incubated for 10 mins by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed