BindingDB BDBM50613394 CHEMBL5278465

BDBM50613394 CHEMBL5278465

SMILES Clc1ccc(cc1)-c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1

InChI Key InChIKey=OYNBEDDKSIPEQC-UHFFFAOYSA-N

Data 52 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50613394

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of PIM1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: 5.90nMAssay Description:Inhibition of GST tagged GSK-3beta (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of RSK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Tyrosine-protein kinase SYK(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of SYK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of FMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Tyrosine-protein kinase JAK3(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Rho-associated protein kinase 1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of ROCK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Rho-associated protein kinase 2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of ROCK2 mutant (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase Srms(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of SRMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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High affinity nerve growth factor receptor(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of TRKA (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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BDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of TRKB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Non-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of TYK2 (0 to 887 residues) (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Activated CDC42 kinase 1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of ACK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Casein kinase I isoform delta(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of CK1D (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Serine/threonine-protein kinase 33(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of STK33 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Tyrosine-protein kinase CSK(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of CSK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Cytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of BMX (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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Interleukin-1 receptor-associated kinase 1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of IRAK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of IKK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Tyrosine-protein kinase JAK1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Golgi-associated PDZ and coiled-coil motif-containing protein(Homo sapiens)TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of CAL (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of PDGFRB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mitogen-activated protein kinase 14(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of MAPK14 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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MAP kinase-activated protein kinase 2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of MK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Aurora kinase A(Mus musculus (mouse))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of mouse Aurora kinase A by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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Insulin-like growth factor 1 receptor(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of cKIT (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of wild type ABL (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Platelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

MMDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

PC cid PC sid

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Non-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of TYK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Mitogen-activated protein kinase 8(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of JNK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase Lck(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of LCK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Tyrosine-protein kinase JAK2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Casein kinase II subunit alpha'(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of CK2A2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Interleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cyclin-dependent kinase 2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Aurora kinase B(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of Aurora-B (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase BTK(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of BTK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Tau-tubulin kinase 2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of TTBK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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Tau-tubulin kinase 1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of TTBK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

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MAP/microtubule affinity-regulating kinase 4(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of MARK4 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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MAP/microtubule affinity-regulating kinase 3(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of MARK3 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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Serine/threonine-protein kinase MARK2(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of MARK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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Serine/threonine-protein kinase MARK1(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of MARK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase Fyn(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >5.00E+4nMAssay Description:Inhibition of FYN (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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TRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of TNIK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase Tec(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of TEC (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: >2.00E+3nMAssay Description:Inhibition of ITK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

BDBM50613394(CHEMBL5278465)

IC50: 200nMAssay Description:Inhibition of GSK-3beta (unknown origin) assessed as decrease in tau phosphorylation by high content cell based assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Displayed 1 to 50 (of 52 total ) | Next | Last >>

Filter my 52 hits

Targets 50▿
- Non-receptor tyrosine-protein kinase TYK2 2
- Glycogen synthase kinase-3 beta 2
- Tyrosine-protein kinase Lck 1
- Tyrosine-protein kinase Tec 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase ITK/TSK 1
- Insulin-like growth factor 1 receptor 1
- High affinity nerve growth factor receptor 1
- Serine/threonine-protein kinase pim-1 1
- Tyrosine-protein kinase JAK1 1
- Mitogen-activated protein kinase 8 1
- Golgi-associated PDZ and coiled-coil motif-containing protein 1
- Tyrosine-protein kinase SYK 1
- Mast/stem cell growth factor receptor Kit 1
- Ribosomal protein S6 kinase alpha-1 1
- Tau-tubulin kinase 1 1
- Tau-tubulin kinase 2 1
- Mitogen-activated protein kinase 14 1
- Aurora kinase B 1
- Aurora kinase A 1
- Glycogen synthase kinase-3 alpha 1
- Tyrosine-protein kinase Srms 1
- Interleukin-1 receptor-associated kinase 4 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Platelet-derived growth factor receptor alpha/beta 1
- Interleukin-1 receptor-associated kinase 1 1
- Casein kinase I isoform delta 1
- Tyrosine-protein kinase ABL1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- MAP/microtubule affinity-regulating kinase 3 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase 33 1
- Cyclin-dependent kinase 2 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- MAP/microtubule affinity-regulating kinase 4 1
- TRAF2 and NCK-interacting protein kinase 1
- Activated CDC42 kinase 1 1
- Rho-associated protein kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- MAP kinase-activated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Platelet-derived growth factor receptor beta 1
- BDNF/NT-3 growth factors receptor 1
- Casein kinase II subunit alpha' 1
Publications 0▿
Institutions 0▿
Affinity: 2 to 5.0E+4 nM▿
- IC50 52
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0