BDBM50613988 CHEMBL5279644

SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(cc2)-c2ncn(n2)C2CC2)c1OC

InChI Key InChIKey=UKJLHSUFJRYTMJ-FIBGUPNXSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50613988   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50613988(CHEMBL5279644)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of TYK2 dependent IFNalpha-stimulated STAT3 phosphorylation in human Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50613988(CHEMBL5279644)
Affinity DataIC50: 972nMAssay Description:Inhibition of JAK1/3 dependent IL-2 stimulated STAT5 phosphorylation in CD3-positive T cells (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50613988(CHEMBL5279644)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of JAK2 dependent GM-CSF stimulated STAT3 phosphorylation in human TF-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed