BDBM50614180 CHEMBL5278505

SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12

InChI Key InChIKey=KWRNFDMMNZXXJC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50614180   

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50614180(CHEMBL5278505)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50614180(CHEMBL5278505)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human VEGFR2 (aa805 to 1356 residues) expressed in baculovirus expression system using Poly- (Glu4:Ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed