BDBM50615194 CHEMBL5268256::US20240092759, Compound 8

SMILES Clc1cccc(c1)-c1cc(cn(-c2cccnc2)c1=O)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=XOPZNMANGWUPLN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50615194   

TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM50615194(CHEMBL5268256 | US20240092759, Compound 8)
Affinity DataIC50: 6.38E+3nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM50615194(CHEMBL5268256 | US20240092759, Compound 8)
Affinity DataIC50: 6.38E+3nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Egyptian Russian University

Curated by ChEMBL
LigandPNGBDBM50615194(CHEMBL5268256 | US20240092759, Compound 8)
Affinity DataIC50: 6.38E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease using Dabcyl-KTSAVLQSGFRKM-E(Edans-NH2) as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Egyptian Russian University

Curated by ChEMBL
LigandPNGBDBM50615194(CHEMBL5268256 | US20240092759, Compound 8)
Affinity DataIC50: 6.38E+3nMAssay Description:Inhibition of SARS-CoV-2 recombinant main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed