BDBM50615677 CHEMBL5289631

SMILES CC(=O)Nc1cc(Oc2ccc(NC(=O)Cc3ccccc3C(F)(F)F)cc2)ncn1

InChI Key InChIKey=PFGNOYJAWUKCEW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50615677   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 24nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 84nMAssay Description:Inhibition of PDGFRalpha (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 91nMAssay Description:Inhibition of FLT3 (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 207nMAssay Description:Inhibition of PDGFRbeta (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 212nMAssay Description:Inhibition of CSF1R (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 681nMAssay Description:Inhibition of KIT (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandPNGBDBM50615677(CHEMBL5289631)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HPK1 (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed