BDBM50616038 CHEMBL5428156

SMILES [H][C@@]1(C[C@@H](C)\C=C/C(=O)[C@H](C)\C=C(/C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(O)=O)OC)CC[C@@H](OCCCCc2cn(CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCCn3nc(-c4ccc5oc(N)nc5c4)c4c(N)ncnc34)nn2)[C@@H](C1)OC

InChI Key InChIKey=ZTXMWXWZYOHCDZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50616038   

TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616038BDBM50616038(CHEMBL5428156)
Affinity DataIC50: 59nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616038BDBM50616038(CHEMBL5428156)
Affinity DataIC50: 180nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed