BDBM50616103 CHEMBL5419931

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](C)C(=O)C(=O)NCCCCc1ccccc1

InChI Key InChIKey=GRZBUTPJWIBTNF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50616103   

TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616103BDBM50616103(CHEMBL5419931)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant C-terminal hexahistidine tagged mature human PARL using Ac-RRRAVFLA-4mc as substrate preincubated for 1 hr followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616103BDBM50616103(CHEMBL5419931)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human PARL using KSp106 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616103BDBM50616103(CHEMBL5419931)
Affinity DataIC50: 150nMAssay Description:Inhibition of human PARL expressed in human HEK293T cells cotransfected human FLAG tagged PGAM5 assessed as inhibition of CCCP induced full length PG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetRhomboid protease GlpG(Escherichia coli (strain K12))
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616103BDBM50616103(CHEMBL5419931)
Affinity DataIC50: 300nMAssay Description:Inhibition of Escherichia coli GlpG extracted from Escherichia coli C43(DE3) using KSp96 as substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616103BDBM50616103(CHEMBL5419931)
Affinity DataIC50: 410nMAssay Description:Inhibition of tetracycline inducible FLAG tagged human PARL expressed in human PARL knockout Flp-In-T-REx-293 cells cotransfected human PGAM5-Myc ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616103BDBM50616103(CHEMBL5419931)
Affinity DataEC50:  445nMAssay Description:Inhibition of tetracycline-inducible FLAG-tagged human PARL stably transfected in HEK293T harboring FITR/PARL KOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed