BDBM50616179 CHEMBL5401710

SMILES COc1ccc(cc1)C2(CCCCC2)C(=O)N3C[C@@H](C[C@@H]3C(=O)Nc4ccc5c(n4)cn[nH]5)F

InChI Key InChIKey=CCRMEUSDGNVQDG-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50616179   

TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616179(CHEMBL5401710)
Affinity DataIC50: 21nMAssay Description:Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular H3K27 acetylation incubated for 3 hrs by chemiluminescence based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616179(CHEMBL5401710)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human full length EP300 assessed as inhibition of H4 peptide acetylation using biotinylated H4 peptide as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)