BDBM50616476 CHEMBL5405779

SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(NCCCCCCC(=O)NO)c21

InChI Key InChIKey=OABQDWQBXSGEDG-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50616476   

TargetHistone deacetylase 6(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 9nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length recombinant human HDAC1 (1 to 482 residues) expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant BRD4 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 113nMAssay Description:Inhibition of recombinant BRD3 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 152nMAssay Description:Inhibition of C-terminal GST-tagged full-length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 161nMAssay Description:Inhibition of His-tagged recombinant human HDAC3 expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 174nMAssay Description:Inhibition of recombinant BRD2 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 221nMAssay Description:Inhibition of recombinant BRDT BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50616476(CHEMBL5405779)
Affinity DataIC50: 784nMAssay Description:Inhibition of C-terminal His-tagged full-length recombinant human HDAC8 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed