BDBM50617043 CHEMBL5416581

SMILES COc1ccc2nc(N[C@H]3CCN(C3)C(=O)Cc3cc(F)cc(F)c3)ccc2c1

InChI Key InChIKey=LDCYRYGDVBLWLI-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50617043   

TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataKi:  0.620nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataIC50: 7.80nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as decrease in alpha-MSH induced cAMP level incubated for 1 hr by microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataIC50: 360nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed