BDBM50617046 CHEMBL5437451

SMILES Cc1nc2N[C@]3(CCN(C3)C(=O)Cc3ccc(F)cc3)CCc2cc1-c1cnn(C)c1

InChI Key InChIKey=OPZFVSWLPKKDNC-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50617046   

TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataKi:  1.70nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataKi:  1.70nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataKi: >220nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataKi: >220nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent